Program Overview

Thursday, April 20, 2017

08:30 – 09:30 am Registration and Coffee
09:30 – 10:00 am Welcome Address

Jean-Marc Gambaudo
President of the University Côte d’Azur

Frédérique Vidal
President of the University Nice Sophia-Antipolis

Patrick Baqué
Dean of the Medical Faculty of Nice

Jean-Jacques Pierrat
Counselor for Science and Technology of the French Embassy in Germany

10:00 – 10:30 am Presidential Lecture
Chairs: Emmanuel Van Obberghen | Hans-Ulrich Häring
CNS-dependent control of glucose metabolism

Jens Brüning

10:30 – 01:00 pm Central Regulation of Metabolism
Chairs: Jens Brüning | Hans-Ulrich Häring
10:30 – 11:00 am

The causes and consequences of human obesity, some insights from genetics
Stephen O’Rahilly

11:00 – 11:30 am

Brain glucose sensing in metabolic and behavioral control
Bernard Thorens

11:30 – 12:00 am

Multiplexing the effects of hepatic insulin resistance through the action of FoxO-regulated hepatokines
Morris White

12:00 – 12:30 pm

Role of brain insulin action in human metabolism
Martin Heni

12:30 – 01:00 pm

Insulin action and cardiovascular outcome
Riccardo Perfetti

01:00 – 03:00 pm Lunch and Poster Session I
03:00 – 05:00 pm Regulation of Metabolism
Chairs: Michael Czech | Henning Beck-Nielsen
03:00 – 03:30 pm

Glycerolipid-Fatty acid cycle : role in cellular signaling and energy homeostasis
Marc Prentki

03:30 – 04:00 pm

Stress response pathways in the inflammation and metabolic dysfunction of adipose tissue
Jean-Francois Tanti

04:00 – 04:30 pm

Novel insights in the regulation of the hepatokine FGF21 by glucose
Catherine Postic

04:30 – 05:00 pm

Insulin resistance in non-alcoholic fatty liver disease
Michael Roden

05:00 – 05:30 pm Coffee break
05:30 – 07:00 pm Genetic Impact on Metabolism
Chairs: Stephen O’Rahilly | Susanne Mandrup
05:30 – 06:00 pm

Genetic and epigenetic impact on metabolic disorders
Martin Hrabě de Angelis

06:00 – 06:30 pm

(Epi)genetics of insulin resisitance
Philippe Froguel

06:30 – 07:00 pm

Towards precision medicine in diabetes
Leif Groop

08:00 – 10:00 pm Welcome Reception at the Hyatt Regency Nice

Friday, April 21, 2017

08:30 – 10:30 am Epigenetic Control of Metabolism
Chairs: Martin Hrabě de Angelis | Anna Krook
08:30 – 09:00 am

Programming by maternal over-nutrition: a developing obesity crisis
Susan Ozanne

09:00 – 09:30 am

Transcriptional networks driving lineage determination of human brown adipocytes
Susanne Mandrup

09:30 – 10:00 am

Epigenetic regulation in obesity and diabetes
Francesco Beguinot

10:00 – 10:30 am

Brown adipose tissue as a critical regulator of fetal programming of adult metabolic disease
Charlotte Hinault

10:30 – 11:00 am Coffee break
11:00 – 12:30 pm Organ Crosstalk I
Chairs: Ulf Smith | Silvia Corvera
11:00 – 11:30 am

Lipogenesis in adipose tissue and the regulation of systemic insulin sensitivity
Barbara Kahn

11:30 – 12:00 am

MicroRNAs and skeletal muscle metabolism
Anna Krook

12:00 – 12:15 pm

Antibiotic treatment modulates physiological and behavioral phenotypes in a model of high-fat feeding [OP-1]
Marion Soto

12:15 – 12:30 pm

Triglycerides sensing in the mesolimbic system and the regulation of food reward [OP-2]
Serge Luquet

12:30 – 01:00 pm Keynote Lecture
Chairs: Masato Kasuga | Eleftheria Maratos-Flier
Jesse Roth and the founding of insulin receptor biology: back to the future
C. Ronald Kahn
01:00 – 03:00 pm Lunch and Poster Session II
03:00 – 05:00 pm Organ Crosstalk II
Chairs: Leif Groop | Eddy Karnieli
03:00 – 03:30 pm

Regulation of beige/brown adipogenesis by BMP agonists and antagonists
Ulf Smith

03:30 – 04:00 pm

Crosstalk between fatty pancreas and fatty liver: effects on local inflammation and insulin secretion
Susanne Ullrich

04:00 – 04:30 pm

Insulin signaling in adipocytes and metabolic control
Wataru Ogawa

04:30 – 04:45 pm

Deletion of Protein Kinase C epsilon in adipose tissue but not in liver improves the suppression of hepatic gluconeogenesis and protects against diet-induced glucose intolerance: transcriptomic and proteomic investigation of tissue crosstalk [OP-3]
Carsten Schmitz-Pfeiffer

04:45 – 05:00 pm

The p66shc protein mediates fatty acid-induced insulin resistance in pancreatic beta-cells [OP-4]
Francesco Giorgino

05:00 – 05:30 pm Coffee break
05:30 – 07:00 pm Brown/Beige Adipose Tissue
Chairs: Phillip Gorden | Barbara Kahn
05:30 – 06:00 pm

Brown and brite/beige fat: handling of glucose and other substrates
Barbara Cannon

06:00 – 06:30 pm

Origin and function of human thermogenic “Brite/beige” adipose tissue
Silvia Corvera

06:30 – 07:00 pm

Role of PKA-activated mTOR in fat cell metabolism and thermogenesis
Sheila Collins

Saturday, April 22, 2017

08:30 – 11:00 am Islets
Chairs: Yehiel Zick | Suanne Ullrich
08:30 – 09:00 am

Noncoding genome function in pancreatic islets
Jorge Ferrer

09:00 – 09:30 am

Growth factor signaling in islet cells
Rohit Kulkarni

09:30 – 10:00 am

Beta cell heterogeneity and regeneration
Heiko Lickert

10:00 – 10:30 am

Induction of pancreatic beta-like cell neogenesis
Patrick Collombat

10:30 – 11:00 am

Modulation of pancreatic β-cell identity by microRNA-375
Olivier Dumortier

11:00 – 11:30 am Coffee break
11:30 – 01:00 pm New Targets and Therapies I
Chairs: C. Ronald Kahn | Jean-Louis Carpentier
11:30 – 12:00 am

Treatment of type 2 diabetes based on pathophysiology
Henning Beck-Nielsen

12:00 – 12:30 pm

Role of insulin receptor substrates in liver and macrophage in obesity-linked insulin resistance
Takashi Kadowaki

12:30 – 12:45 pm

Apelin administration improves insulin sensitivity in overweight healthy men: a phase 1 randomised, double-blind placebo-controlled cross-over trial [OP-5]
Isabelle Laurell

12:45 – 01:00 pm

A GLP-1R/GCGR dual agonist exhibits differential effects on metabolic control versus a single GLP-1R agonist by activation of BAT and browning in diet-induced obese mice [OP-6]
Angela Valverde

01:00 – 03:00 pm Lunch and Poster Session III
03:00 – 04:30 pm New Targets and Therapies II
Chairs: Morris White | Barbara Cannon
03:00 – 03:30 pm

Gene therapy approaches for diabetes
Fatima Bosch

03:30 – 04:00 pm

FGF21 actions in mouse and man: potential for treatment in metabolic disease
Eleftheria Maratos-Flier

04:00 – 04:30 pm

Optimizing gut-brain communication for metabolic health
Matthias Tschöp

04:30 – 05:00 pm Coffee break
05:00 – 06:30 pm 05:00 – 05:30 pm

Dual peptides: Too good to be true?
Cristina Rondinone

05:30 – 06:00 pm

The chemical evolution of insulin and related peptides
Richard DiMarchi

Perspectives for Diabetes/Farewell
Chairs: Emmanuel Van Obberghen | Hans-Ulrich Häring
06:00 – 06:30 pm

Looking to a CRISPR future in diabetes research and therapies
Michael Czech

08:00 – 11:00 pm Farewell Dinner at the Hotel Negresco